Efficient delivery of siRNAs by a photothermal approach using plant flavonoid-inspired gold nanoshells.

نویسندگان

  • Eun Hye Jeong
  • Ji Hyun Ryu
  • Hansaem Jeong
  • Bora Jang
  • Ho Yeon Lee
  • Seonki Hong
  • Haeshin Lee
  • Hyukjin Lee
چکیده

Polymer gold nanoshells (PGNs) are prepared by a novel plant-inspired flavonoid surface modification method. The PGNs show dramatic photothermal properties, which can facilitate the endosomal escape and delivery of siRNA into the cytoplasm of cells. Efficient gene silencing has been achieved using siRNA immobilized PGNs, suggesting the potential applications of in vitro gene regulation by an external NIR stimulus.

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Efficient Delivery of siRNAs by Photothermal Approach using Plant Flavonoid-inspired Gold Nanoshells**

Please note that technical editing may introduce minor changes to the text and/or graphics, which may alter content. The journal’s standard Terms & Conditions and the Ethical guidelines still apply. In no event shall the Royal Society of Chemistry be held responsible for any errors or omissions in this Accepted Manuscript or any consequences arising from the use of any information it contains. ...

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عنوان ژورنال:
  • Chemical communications

دوره 50 87  شماره 

صفحات  -

تاریخ انتشار 2014